爱斯坦-巴尔病毒编码的潜膜蛋白2A通过在扩散型大B细胞淋巴瘤中对SYK/核因子-κB信号进行升级来促进免疫逃生

Xiang-Nan Jiang1, Dong Sheng1, Wan-Hui Yan1

  • 1Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Institute of Pathology, Fudan University, Shanghai, China.

概括

埃普斯坦-巴尔病毒 (EBV) 编码的潜膜蛋白2A (LMP2A) 通过激活SYK/NF-κB信号,促进EBV阳性扩散型大B细胞淋巴瘤 (DLBCL) 的免疫逃逸,从而导致PD-L1表达的增加,并促进免疫逃逸.

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