环境友好型高药载量微乳液与内置深度环氧溶剂:通过双重奥佐效应提高精度
Junxiao Zhu1, Tianjian Ye2, Mi Tang3
1School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, PR China; School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, PR China.
International journal of pharmaceutics
|February 6, 2025
概括
这项研究引入了一种新型的双OUZO效应微乳液,使用深度性溶剂 (DES) 来增强药物输送. 该系统显著提高了黄素的溶解性和稳定性,克服了传统方法的局限性.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 制药科学 制药科学
背景情况:
- 深度浸泡溶剂 (DES) 提高了药物溶解度,但需要提供系统.
- 奥佐效应允许无表面活性剂的微乳液,但受到油相比的限制.
研究的目的:
- 开发一个双Ouzo效应微乳液系统,将DES集成为油相.
- 同时诱导微乳液和纳米沉以提高药物输送.
- 控制颗粒大小,提高黄素的可溶性和稳定性.
主要方法:
- 在双重OUZO效应系统中,使用深度性溶剂 (DES) 作为油相.
- 分析了组合图,以精确调整VA64与二醇的质量比.
- 研究了黄素的溶解性,在暴露于光线下的稳定性和释放动力学.
- 测量了三相接触角,以评估接口稳定性.
主要成果:
- 实现了同时的微乳液和纳米沉,控制了从200-550nm的粒子大小.
- 提高了黄素的溶解度,达到17.11 mg/mL (增加了1700倍),具有卓越的稳定性 (22.4%的降解与90-95%相比).
- 通过增强的分子相互作用和超和,使油相比从0.05%增加到30%.
- 证明了最佳的微乳液稳定性,接触角度为89.2°.
结论:
- 开发的双Ouzo效应微乳液系统有效地提高了药物的溶解性和稳定性.
- 整合DES通过增加允许的油相比度来扩大奥佐效应的适用性.
- 这种方法为开发药物输送系统提供了一种有希望,稳定和高效的方法.
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