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基于肠道微生物和代谢物差异的多维探索在患有复发性中风的患者中

Zongwei Fang¹, Sijie Chang¹, Peiguang Niu¹

¹Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.

|February 6, 2025

概括

再发性中风患者表现出改变的肠道微生物群和代谢物,包括像Lachnospiraceae_UCG-010.10这样的有益细菌枯竭. 这些肠道变化可能会影响中风复发和通过肠-大脑轴的进展.

科学领域:

微生物学微生物学
神经学神经学
代谢学代谢学代谢学

背景情况:

肠道微生物群-代谢物-大脑轴在神经疾病中起作用.
了解中风患者的肠道微生物和代谢差异对于管理复发至关重要.

研究的目的:

为了研究最初的中风 (Os) 和复发性中风 (Rs) 患者之间的肠道微生物和代谢物变异.
为了确定潜在的肠道微生物群-代谢物生物标志物用于缺血性中风进展.

主要方法:

便样本分析了肠道微生物群组成和代谢物概况.
进行了贝塔多样性分析 (Bray-Curtis,UniFrac).
相关性分析将微生物和代谢物变化与中风复发风险联系起来.

主要成果:

在OS和RS组之间的α多样性没有显著差异.
观察到社区组成的轻微变化 (Beta多样性).
在Rs组显示了Prevotella,Lachnospiraceae_UCG-010,Holdemanella和Coprococcus的枯竭.
上调的碳水化合物和酸乳;下调的酸,三酸和脂肪酸.
在阿拉基酸,贝他因和亚麻酸代谢途径中的丰富.
Rs的特点是减少无氧细菌和短链脂肪酸 (SCFA) 生产细菌.

结论:

在最初和复发性中风患者之间,肠道微生物群和代谢物配置不同.
Lachnospiraceae_UCG-010 枯竭与中风复发风险有负相关性.
阿拉基酸和酸代谢途径的改变可能会导致缺血性中风的进展.

关键词:

毒品的目标是毒品.肠道微生物肠道微生物缺血性中风是因为缺血性中风.代谢物的代谢物.

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