在没有糖尿病的中国成年人中使用甘油三-葡萄糖-腰围增强中风风险分层
1Department of Clinical Nutrition, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
American journal of preventive medicine
|February 6, 2025
概括
三甘油-葡萄糖-腰围 (TyG-WC) 指数有效预测没有糖尿病的人中风风险. 与其他甘油三糖指数相比,这种修改后的指数提供了优越的风险分层.
科学领域:
- 心血管疾病的研究研究.
- 代谢综合征标志物 代谢综合征标志物
- 脑卒中流行病学 脑卒中流行病学
背景情况:
- 胰岛素抵抗是已知的中风风险因素.
- 三糖-葡萄糖 (TyG) 指数及其对非糖尿病人群中风的修改形式的预测值尚不清楚.
研究的目的:
- 调查TyG指数及其修改指数 (TyG-WC,TyG-WHtR,TyG-BMI) 与中风风险之间的关联.
- 为了比较这些指数在没有糖尿病的成年人中的预测性表现.
主要方法:
- 来自查尔斯研究 (2011-2020年) 的45岁以上的4029名非糖尿病参与者的数据分析.
- 在2015年至2020年期间检查了事件中风.
- 基于基线水平,随时间的变化 (K-means聚类) 和累积措施,分析了TyG指数.
主要成果:
- 三甘油-葡萄糖-腰围 (TyG-WC) 指数与基线,变化和累积措施的中风风险有显著的相关性.
- 与TyG,TyG-WHtR和TyG-BMI相比,TyG-WC显示了对中风的优异预测性能.
- 提升的TyG-WC水平与中风风险增加有关 (例如,AOR从1.61到1.80不等).
结论:
- TyG-WC指数是非糖尿病人群中中风风险的强有力的预测指标.
- 与其他基于TyG的指数相比,TyG-WC提供了加强的中风风险分层.
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