Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

48
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
48
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

61
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
61

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Longitudinal circulating tumour DNA identifies patients at high risk of upstaging and recurrence in non-muscle-invasive bladder cancer.

BJU international·2026
Same author

Case of Basal Cell Prostate Cancer and Recurrence With Prostatic Adenocarcinoma in a United States Military Veteran Exposed to Agent Orange.

Clinical case reports·2026
Same author

Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.

Research square·2026
Same author

Trophoblastic-Differentiated Urothelial Carcinoma: Real-World Sequencing and Clinical Implications.

Clinical genitourinary cancer·2026
Same author

Preoperative Tumor-Informed ctDNA for Prediction of Nodal Metastases at Radical Cystectomy in Bladder Cancer.

Annals of surgical oncology·2026
Same author

Effect of desflurane versus propofol on perioperative neurocognitive disorders in older adults undergoing major urological surgery: a randomized trial.

BMC geriatrics·2026

相关实验视频

Updated: May 29, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

446

一种基于人工智能的全自动化方法,用于预测彻底或部分切除术后的功能.

Nour Abdallah1, Nityam Rathi1, Nicholas Heller2

  • 1Glickman Urological and Kidney Institute, Cleveland, OH.

Urology
|February 6, 2025
PubMed
概括

一个人工智能 (AI) 模型准确预测术后功能,与临床模型相匹配. 这种人工智能工具提供了一个精确的,自动化的方法来估计膜过率 (GFR) 脏手术后.

更多相关视频

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.4K
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.0K

相关实验视频

Last Updated: May 29, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

446
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.4K
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.0K

科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 人工智能在医学中的应用
  • 医疗成像医学成像

背景情况:

  • 美国泌尿学会建议估计手术后的膜过率 (GFR),以指导瘤治疗.
  • 如果预计GFR在术后降低到45毫升/分钟/1.73平方米以下,则偏偏腎切除术 (PN) 优先于彻底腎切除术 (RN).
  • 目前用于GFR预测的已验证模型在临床采用方面仅受限.

研究的目的:

  • 评估人工智能 (AI) 模型在预测术后GFR方面的准确性,与验证的临床模型相比.
  • 评估AI在对接受切除术的患者进行GFR估计的自动化中的实用性.
  • 为了确定AI预测是否可以与已建立的临床方法的性能相匹配.

主要方法:

  • 使用深度学习细分模型,从手术前的CT扫描中确定分功能.
  • 术后GFR使用基于手术前GFR和分裂功能的人工智能驱动的计算来估计.
  • 还使用了一种经过验证的临床模型来估计术后GFR.
  • 人工智能和临床模型的估计与使用相关系数和逻辑回归来预测GFR<45的术后GFR进行了比较.

主要成果:

  • 人工智能模型实现了0.75的相关系数,而临床模型与手术后GFR相比,达到0.77.
  • 这两种模型在预测术后GFR<45时表现相似,AI的曲线下面面积为0.89,临床模型为0.9.
  • 这项研究包括300名因脏瘤而接受脏切除术的患者.

结论:

  • 全自动化的人工智能模型用于预测新的基线功能,与验证的临床模型一样准确.
  • 人工智能方法消除了对额外临床细节或手动测量的需求,简化了预测过程.
  • 这种人工智能工具为临床实践中术后GFR估计提供了一个可行的,自动化的替代方案.