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相关概念视频

Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
687
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

305
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
305
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Inhaled Medications01:23

Inhaled Medications

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Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
220
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

374
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
374

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相关实验视频

Updated: May 29, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

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革命性的固定剂量组合与长效微球.

Zhenhua Hu1, Xiao Xiao2, Guiyun Zhang2

  • 1Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|February 6, 2025
PubMed
概括

需要长效的固定剂量组合 (FDC) 来改善患者的坚持治疗. 微球技术为开发这些持续释放的FDC提供了一个有前途的方法,提高治疗效果.

关键词:
慢性疾病 慢性疾病 慢性疾病固定的剂量组合.长效的 长效的微球微球是指微球的小部分.

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Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 药物输送系统 药物输送系统
  • 生物技术是生物技术.

背景情况:

  • 组合疗法对于管理复杂疾病至关重要.
  • 固定剂量组合 (FDCs) 提高治疗结果,但通常需要频繁的剂量.
  • 传统的FDC导致患者不良的遵从性和不一致的治疗,特别是在慢性疾病中.

研究的目的:

  • 为了突出长期起作用的FDC的需求.
  • 为了强调持续的药物释放和降低剂量频率.
  • 为了改善患者的坚持和治疗结果.

主要方法:

  • 对FDC和药物输送系统的当前文献的审查.
  • 专注于微球技术,用于封装多种药物.
  • 持续释放模式和患者合规因素的分析.

主要成果:

  • 长效的FDC在慢性疾病管理中越来越需要.
  • 微球技术可实现精确的封装和多种药物的受控释放.
  • 持续释放减少了剂量频率,可能改善了粘附性.

结论:

  • 微球技术是开发先进的长效FDC的一个有希望的方法.
  • 这项技术可以通过提高疗效和患者遵从性来彻底改变FDC疗法.
  • 对基于微球的FDC进行进一步的研究是有必要的,以改善患者护理.