基于技术的替代疗法的未来:关于便携式,可穿戴式和可植入式人工的最新情况
Fokko P Wieringa1, Swathi Suran2, Henning Søndergaard3
1imec, Holst Centre, Eindhoven, The Netherlands; Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands; European Kidney Health Alliance Work Group 3 "Breakthrough Innovation," Brussels, Belgium; International Electrotechnical Commission TC62D/MT20, Geneva, Switzerland.
概括
数以百万计的需要置换疗法 (KRT) 的患者无法获得. 移动透析和生物反应器等创新可以提高KRT的可访问性和可负担性,克服基础设施障碍.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物技术是生物技术.
- 公共卫生 公共卫生
背景情况:
- 全球对置换疗法 (KRT) 的需求日益增长与有限的获取方式形成鲜明对比,导致可预防的死亡.
- 目前的KRT (移植,腹膜透析,血液透析) 在可访问性,成本和基础设施依赖性方面面临限制.
- 异种移植显得有前途,但需要进一步发展;自20世纪80年代以来,现有的透析方法几乎没有创新.
研究的目的:
- 探索基于移动技术的创新方法,以增加获得替代疗法 (KRT) 的机会.
- 确定克服KRT基础设施,经济和物流障碍的战略.
- 为了加快KRT创新的步伐,与成功的技术采用模式进行并行.
主要方法:
- 审查KRT的新兴技术,包括透析剂再生和基于芯片的纳米多孔过器.
- 研究生物反应器支持技术和使用肠道作为"第三脏"的概念.
- 分析移动技术采用模式的潜力,类似于"非洲移动电话革命",以增强KRT交付.
主要成果:
- 确定的有前途的技术包括先进的过,透析剂再生和生物综合系统.
- "第三脏"概念和移动KRT解决方案有可能绕过传统基础设施需求.
- 国际合作和以患者为中心的方法 ("合作") 对于快速进步至关重要.
结论:
- 创新的,以移动为中心的KRT解决方案对于解决全球接入差距至关重要.
- 需要大量投资和国际合作才能实现KRT创新路线图中概述的目标.
- 从移动技术革命中吸取教训可以加速开发和部署拯救生命的KRT.
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