客观习惯指标与客观药物坚持之间的相关性:对15818名临床研究参与者的回顾性研究
Antoine Pironet1, L Alison Phillips2, Bernard Vrijens1
1AARDEX Group, Seraing, Belgium.
Interactive journal of medical research
|February 6, 2025
概括
对药物服用习惯的客观测量与药物坚持相关. 每日药物服用时间变化较低表明更好的坚持,这表明习惯指标可以监测患者并指导支持.
科学领域:
- 药理学和卫生服务研究 研究 药理学和卫生服务研究
- 行为科学和患者的坚持
背景情况:
- 药物坚持是全球性的挑战,全球患者的遵守率低于最佳水平.
- 改善药物服用习惯提供了一种潜在的策略,以提高药物坚持.
- 当前的习惯指标通常是自我报告的,并且有局限性;客观措施正在出现.
研究的目的:
- 使用大型数据集调查客观习惯指标和客观药物坚持之间的关系.
- 量化每日和每周药物摄入量变化和坚持率之间的相关性.
主要方法:
- 使用了药物事件监测系统遵守知识中心数据库,其中包含电子药物摄入数据.
- 分析了至少14天内每天服用一次治疗方案的参与者的数据.
- 计算了两个客观的习惯指标:摄入时间的标准偏差和摄入时间的每周交叉相关性.
- 按服用剂量的比例和正确日数的比例量化药物坚持.
主要成果:
- 分析了来自108项临床研究的15818名参与者的数据集,主要是高血压和骨质疏松症.
- 摄入小时的较低标准偏差 (较少的每日变化) 与坚持度指标负相关 (正确天的ρS=-0.62,P<.001).
- 较高的每周交叉相关性 (较少的每周变异性) 与坚持度指标正相关 (正确天的ρS=0.55,P<.001).
- 习惯强度解释了超过30%的药物坚持差异.
结论:
- 客观的习惯指标表明与客观的药物坚持有显著的相关性.
- 这些指标可以作为监测患者遵守规则的宝贵工具.
- 客观的习惯指标可以帮助识别那些可以从干预中获益的患者,以建立服用药物的习惯.
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