来自Fructus Corni的两种多糖的结构及其对胰岛素抵抗的保护作用
Guang-Yuan Ma1, Lu-Kuan Hou1, Jia-Hui Guo1
1Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
一种Fructus Corni多糖,PFC-CI,通过改善葡萄糖吸收和胰岛素敏感性,有效地对抗2型糖尿病. 它向Glut2/glucokinase通路,为糖尿病管理提供一种天然治疗方法.
科学领域:
- 自然产品化学 自然产品化学
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2DM) 涉及胰岛素抵抗和葡萄糖处理受损,缺乏确定的治疗方法.
- 来自自然来源的多糖体显示出T2DM预防和治疗的潜力.
研究的目的:
- 从Fructus Corni中分离和表征多糖因其抗糖尿病特性.
- 为了评估这些多糖的有效性,T2DM的体外和体外模型.
主要方法:
- 从Fructus Corni.中分离和阐明两个多糖的结构,PFC-CI和PFC-CII.
- 在体外评估胰岛素抵抗性HepG2细胞的葡萄糖消耗和吸收.
- 在高脂肪饮食和链毒素诱导的糖尿病大鼠模型中PFC-CI的体内评估.
主要成果:
- 与PFC-CII (26.0 kDa) 相比,PFC-CI (59.0 kDa) 在胰岛素抵抗细胞中显示出优异的葡萄糖吸收促进.
- 在T2DM的老鼠模型中,PFC-CI显著减轻了胰岛素抵抗.
- 发现PFC-CI可以调节葡萄糖转运体2 (Glut2) /葡萄酶信号通路.
结论:
- 果实科尼含有一种强大的多糖,PFC-CI,具有显著的抗T2DM活性.
- PFC-CI作为Glut2的特定调节剂,证明了T2DM的治疗潜力.
- 这项研究强调了Fructus Corni多糖类作为T2DM治疗的有前途的天然药物.
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