双酸盐治疗的变化趋势:在一个单一的美国综合医疗系统中进行了25年的监测
Joan C Lo1,2,3, Malini Chandra4, Mehreen M Khan5,6
1Division of Research, Kaiser Permanente Northern California, 4480 Hacienda Drive, Pleasanton, CA, 94588, USA. Joan.C.Lo@kp.org.
概括
双酸盐 (BP) 用于骨折预防的治疗越来越多地针对老年人和以前骨折的人. 这项为期25年的研究表明,在美国大型医疗保健系统中,实践模式不断变化.
科学领域:
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 双酸盐 (BP) 药物是预防骨折的第一线治疗方法.
- 在过去的25年里,双酸盐的治疗模式发生了变化.
- 了解这些趋势对于优化骨折预防策略至关重要.
研究的目的:
- 检查50-89岁成年人中双酸盐启动的时间趋势.
- 分析患者的特征 (年龄,性别,骨折史) 如何随着时间的推移而变化.
- 评估有针对性的骨折预防计划对治疗模式的影响.
主要方法:
- 从1998年到2022年,对212,289名成年人开始服用双酸盐 (阿伦德罗酸盐,瑞塞德罗酸盐,伊班德罗酸盐,佐尔德罗酸盐) 的回顾性分析.
- 数据来自北加利福尼亚州Kaiser Permanente,一个大型综合医疗保健系统.
- 分析了5年期间的患者人口统计 (年龄,性别,种族/种族) 和骨折史.
主要成果:
- 双酸盐的开始转向了老年人群 (年龄<65岁在2008年之后显著下降).
- 患有先前骨折的患者比例增加,尤其是在实施二次骨折预防计划后.
- 电子健康记录 (EHR) 对骨矿物质密度 (BMD) 查的目标与持续治疗的开始相吻合.
结论:
- 双酸盐治疗的启动越来越多地集中在老年人和有骨折史的人身上.
- 有针对性的骨折预防计划在塑造这些治疗趋势方面发挥着关键作用.
- 这些发现强调了在骨折预防策略中持续努力的重要性.
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