皮炎患者的感染和治疗的影响
Maddalena Napolitano1, Maria Esposito2,3, Maria Concetta Fargnoli4
1Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
American journal of clinical dermatology
|February 6, 2025
概括
患有阿托皮炎 (AD) 的患者面临着由细菌和病毒引起的皮肤感染的更高风险,原因是免疫力和皮肤屏障受损. 有效的AD管理是预防和治疗这些感染的关键.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 亚托皮炎 (AD) 是一种慢性T助手2介导的炎症性皮肤疾病.
- 患有阿尔茨海默病的患者经常出现皮肤和器官感染,疾病严重程度恶化.
研究的目的:
- 审查目前关于亚托皮性皮肤炎患者感染的原因,机制,治疗和预防的证据.
- 突出感染对阿尔茨海默病的影响,并为治疗选择提供信息.
主要方法:
- 在PubMed的系统文献搜索中搜索到2023年2月为止的英语文章.
- 关键词包括"皮炎"和与感染相关的术语.
- 包括研究文章,评论,元分析和指导方针.
主要成果:
- 由于皮肤屏障和免疫反应受损,阿尔茨海默病患者患有细菌 (金黄色葡萄球菌),病毒 (简单疹病毒) 和真菌感染的风险增加.
- 常见的感染包括疹疹,疹炎和毛囊炎,对诸如败血症等全身感染的易感性增加.
- 系统性AD治疗 (例如,JAK抑制剂) 可以提高病毒感染风险.
结论:
- 预防和管理AD的感染需要一个全面的战略:局部/全身抗菌药物,勤奋的皮肤护理,和强大的AD症状控制,以减轻-痕周期.
- 感染风险是选择适当的皮炎治疗方法的关键因素.
相关概念视频
01:23Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
01:26Factors Affecting the Risk of Infection
11.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.0K