不同的耐力训练强度提高了GFR,并在诱导的脏病大鼠中调节了AQP2/GSK3β
Shadan Saberi1, Mohammad Amin Rajizadeh2, Mohammad Khaksari3
1Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
BMC nephrology
|February 6, 2025
概括
高强度运动显著保护诱导脏病的老鼠的功能. 量身定制的运动可以预防长期疗法患者的损伤.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 长期治疗双相情感障碍的疗法可能会导致毒性,导致膜过率 (GFR) 降低和潜在的末期病 (ESRD).
- 不同强度的运动对引起的损伤的影响尚不清楚.
研究的目的:
- 为了研究不同强度的耐力训练对功能和炎症的影响,在诱导的脏病的小鼠模型中.
- 评估关键蛋白质的表达:水素2 (AQP2),糖原合成酶激酶3-β (GSK-3β) 和SIRT1.
主要方法:
- 35只雄性Wistar大鼠被分为五组:对照组,仅,和与低,中,或高强度的运动 (LIT,MIT,HIT) 八周.
- 通过部分分泌 (FENa) 和肌素清除 (Cr清除) 来评估功能.
- 炎症标记物 (TNF-α,IL-10) 和蛋白质表达 (SIRT1,GSK-3β,AQP2) 用ELISA和西式斑点分析.
主要成果:
- 的使用降低了 Cr 清除,增加了 FENa. 所有运动强度都改善了Cr清除和减少FENa,HIT显示了最显著的好处.
- 运动通过减少TNF-α和增加IL-10减轻炎症. MIT和HIT显著增加了SIRT1水平.
- 降低了GSK-3β和AQP2的表达,而所有强度的运动都提高了这些保护性蛋白质的调节.
结论:
- 高强度耐力训练有效减轻引起的功能障碍,改善GFR和减少炎症.
- 运动可以增强脏保护蛋白的表达 (SIRT1,GSK-3β,AQP2),抵消的有害作用.
- 量身定制的运动方案可能是预防长期治疗患者损伤的有价值策略.
相关概念视频
01:28Glomerular Filtration Rate and its Regulation
2.2K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
2.2K
01:32Filtration and Urine Formation
49.3K
The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
49.3K
01:17Factors Affecting Renal Clearance: Renal Impairment
48
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
48
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
375
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
375
01:33Hormonal Regulation
32.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.8K
01:02Renal Drug Excretion: Glomerular Filtration
128
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
128