肌肉质量指数与胰岛素抵抗和2型糖尿病相关:一个基于人口的横截面研究
Mengye Zhang1, Hao Lin2, Xue Xu3
1Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou City, China.
BMC public health
|February 6, 2025
概括
低肌肉质量指数 (MQI) 与胰岛素抵抗 (IR) 和2型糖尿病 (T2DM) 的更高风险有关. MQI可以作为识别这些疾病的有价值标记.
科学领域:
- 代谢健康 代谢健康
- 生物标志物 生物标志物
- 流行病学 流行病学
背景情况:
- 肌肉质量指数 (MQI),计算为握力除以骨肌肉质量,是一种新兴的健康指标.
- 关于MQI,胰岛素耐药性 (IR) 和2型糖尿病 (T2DM) 之间的关联存在有限的研究.
研究的目的:
- 调查MQI与美国成年人中IR和T2DM流行率之间的相关性.
- 评估MQI作为IR和T2DM的潜在诊断标记物的实用性.
主要方法:
- 来自2816名参与者的NHANES数据 (2011-2014) 的横截面分析.
- 进行了多变量逻辑回归,受限立方线回归 (RCS) 和子组分析.
- 用接收器操作特征 (ROC) 曲线分析来比较MQI与单个组件 (骨肌肉质量和握力).
主要成果:
- 在MQI和IR (OR=0.708) 和T2DM (OR=0.676) 的患病率之间观察到显著的负线性相关性.
- 亚组分析表明,在肥胖个体中,MQI和IR之间存在更强的关联.
- 与单独的骨肌肉质量和握力相比,MQI显示出更高的诊断准确性 (IR的AUC=0.679,T2DM的0.688).
结论:
- 降低MQI水平与发展IR和T2DM的风险增加有关.
- MQI显示出作为可靠和可访问的生物标志物的潜力,用于识别面临IR和T2DM风险的个体.
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