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Updated: May 29, 2025

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

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异常表达的核因子 (红状腺衍生2) -Like 2通过调节CD4+ T淋巴细胞的激活和分化,参与aGVHD

Xu Chen1,2,3, Yue Zhang1,2,3, Yan Chen1,2,3

  • 1Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Transplantation
|February 7, 2025
PubMed
概括

核因子 (红色素衍生2) 类似2 (NRF2) 在急性移植与宿主疾病 (aGVHD) CD4+ T细胞中被上调,导致T细胞激活并加剧aGVHD. 抑制NRF2通过降低关键信号通路的调节来降低aGVHD的严重程度.

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