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肠道微生物群及其在心血管疾病发展中的作用
Carlos Escobar1, Xavier Aldeguer2, David Vivas3,4
1Cardiology Department, University Hospital La Paz, Madrid, Spain.
Expert review of cardiovascular therapy
|February 7, 2025
概括
肠道微生物群失生症通过改变的代谢物和肠道透性,有助于心血管疾病风险. 诸如饮食修改和便微生物群移植等干预措施在恢复平衡和降低疾病风险方面表现有前途.
科学领域:
- 微生物学 微生物学
- 心脏病学 心脏病学
- 代谢学 代谢学 代谢学
背景情况:
- 心血管疾病 (CVD) 涉及复杂的遗传和环境因素,即使管理了传统的风险因素,仍然存在残留风险.
- 肠道微生物群在心血管疾病病理生理学中的作用是一个新兴的研究领域.
研究的目的:
- 审查肠道微生物群在心血管疾病发展中的潜在作用.
- 探索肠道微生物群作为潜在的心血管疾病治疗点.
主要方法:
- 在PubMed (MEDLINE) 进行了系统的文献搜索,截至2024年10月30日.
- 搜索术语包括"肠道微生物群"",失生症"",心血管"",TMAO"",胆酸"和"短链脂肪酸".
主要成果:
- 失生症的特点是微生物多样性减少,代谢产量改变 (例如,三甲基胺N氧化物,短链脂肪酸),肠道透性增加,胆酸代谢发生变化.
- 这些变化导致炎症,氧化应激,内皮功能障碍,以及肥胖,高血压,糖尿病,动脉样硬化和心力衰竭等疾病的出现.
结论:
- 通过饮食改变,益生菌,益生菌或便微生物移植恢复肠道微生物平衡可能会对心血管疾病风险因素和结果产生积极影响.
- 准肠道微生物群代表了对心血管疾病的有希望的治疗策略.
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