怀孕不良后果,家族性倾向和心血管风险:瑞典全国性的研究
Ängla Mantel1,2, Charlotte Lindblad Wollmann1,2, Jonas Faxén3,4
1Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institute, Maria Aspmans gata 30A, Stockholm 171 64, Sweden.
European heart journal
|February 7, 2025
概括
有不良妊娠结果 (APO) 的女性心血管疾病 (CVD) 风险增加. 他们的姐妹也面临中度增加的心血管疾病风险,这表明他们有共同的遗传或环境因素.
科学领域:
- 心血管流行病学心血管流行病学
- 生殖健康 生殖健康
- 遗传学和家族风险
背景情况:
- 怀孕不良结果 (APO) 是心血管疾病 (CVD) 的女性特异性风险因素.
- 假设APO和CVD之间有共同的家族敏感性,但未被充分探索.
- 这项研究通过比较女性的心血管疾病风险,研究了家族性倾向,比较了女性的APO及其无APO姐妹.
研究的目的:
- 评估不良妊娠结果 (APOs) 和心血管疾病 (CVD) 之间的家族联系.
- 为了确定APO妇女的姐妹是否有心血管疾病的风险增加.
- 探索APO-CVD协会的共同遗传和/或环境影响.
主要方法:
- 准实验性的家庭比较设计,使用全国性的瑞典登记 (1992-2021年).
- 队列包括具有APO的原发性女性 (n=165,628),他们的无APO姐妹 (n=60,769) 和无关的无APO比较者 (n=992,108).
- 对主要不良心脏事件 (MACE) 的长度随访,包括缺血性心脏病,心力衰竭和脑血管事件.
主要成果:
- 暴露于APO的女性比无APO的对照者显示出更高的心血管疾病率.
- 与比较者相比,没有阿波的姐妹有MACE (aHR1.39),心力衰竭 (aHR1.65) 和脑血管事件 (aHR1.37) 的风险增加.
- 家庭内分析表明,在没有APO的姐妹中,心血管疾病的发病率低于暴露在APO中的姐妹,除了脑血管事件.
结论:
- 患有APO的妇女的姐妹经历了心血管疾病的中等风险.
- 研究结果表明,APO和CVD之间存在着共同的遗传和/或环境倾向.
- 强调有针对性的预防策略的必要性,以帮助患有APO的妇女及其女性亲属.
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