在状细胞疾病中与青相关的生物标志物:系统性审查
Oluwafolajimi Adesanya1, Arthur L Burnett1
1Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287-2101, United States.
Sexual medicine reviews
|February 7, 2025
概括
在状细胞疾病 (SCD) 中的青症缺乏可靠的预测生物标志物. 目前的临床和实验室标记显示出矛盾的结果,需要进一步研究以准确识别风险.
科学领域:
- 血液学 血液学 血液学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 遗传学 遗传学 是一个
背景情况:
- 青春素是一种状细胞疾病 (SCD) 的严重并发症,严重影响患者的性,生殖和心理健康.
- 目前,还没有确立的诊断生物标志物来识别患有SCD的个人在发生前处于 priapism 风险.
研究的目的:
- 系统地审查与SCD患者的前症相关的生物化学,血液学,成像学,遗传学和风湿学参数.
- 在SCD患者中描述潜在的priapism生物标志物的风景.
主要方法:
- 在MEDLINE,Embase和Cochrane数据库中进行了系统的文献搜索.
- 关键词包括"嗜食症"",状细胞"",生物标记物"",标记物"",实验室"",放射性"",诊断"和"预测".
- 在2005年至2023年间发表的14项研究被选为证据综合.
主要成果:
- 调查了多个参数,包括生物化学 (例如,LDH,白血素),血液学 (例如,血红蛋白,网细胞计数),遗传学,学和成像学标记.
- 然而,在所选的研究中,研究结果往往是矛盾的.
- 目前的证据不支持任何研究的参数用于预测SCD中priapism的临床应用.
结论:
- 虽然几个参数已与SCD中的priapism有关,但不一致的发现阻碍了临床实用性.
- 需要更多高质量的证据来验证任何潜在的生物标志物,以预测SCD患者的前风险.
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