胎蛋白-B和氧化压力在母亲营养不良期间破坏胎盘 trofhoblasts
Mia Camilliere1, Marella R Verde2, Michael S Wolin2
1Department of Pathology, New York Medical College, Valhalla, NY, USA.
概括
怀孕期间的孕产妇营养不良 (MUN) 会增加胎蛋白-B和氧化应激,导致胎盘缺陷. 这项研究确定了改善 MUN 中胎盘健康的治疗点. (33个单词) 的意思.
科学领域:
- 生殖生物学 生殖生物学
- 孕产妇和胎儿的医学
- 生物化学 生物化学
背景情况:
- 怀孕期间的孕产妇营养不良 (MUN) 对母亲和胎儿都有风险.
- MUN可以损害关键的胎盘接口.
- 胎盘B蛋白增加和氧化应激被怀疑是导致MUN相关的胎盘缺陷的因素.
研究的目的:
- 调查蛋白-B和氧化应激在由母亲营养不良引起的胎盘缺陷中的作用.
- 建立一个动物模型来研究MUN及其对胎盘的影响.
- 为了确定 MUN 诱导的胎盘功能障碍的潜在治疗干预措施.
主要方法:
- 开发了一种使用卡路里限制,低蛋白饮食的老鼠 MUN 模型.
- 评估了胎盘和热囊细胞病理,包括亡,增殖和氧化应激标志物.
- 研究了fetuin-B对 trofhoblast 功能和线粒体活动的影响.
- 利用制药干预来探索特定的分子途径.
主要成果:
- 孕产妇的营养不良和氧化压力调节了胎盘B蛋白,创造了一个正反循环,通过TLR4激活加剧了氧化压力.
- MUN和升高的fetuin-B水平促进了 trofhoblast 的亡和减少了增殖,减少了 trofhoblast 的数量.
- MUN和fetuin-B都影响了线粒体的新陈代谢和功能,导致 trofhoblasts 中线粒体的超氧化物产生增加.
结论:
- 阐明了将母亲营养不良,B蛋白和氧化应激与胎盘缺陷联系起来的机制.
- 在MUN条件下,确定了fetuin-B作为胎盘功能障碍病变的关键调解者.
- 突出潜在的治疗药物用于管理与母亲营养不良相关的胎盘并发症.
更多相关视频
11:44A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
Published on: September 27, 2017
11.4K
12:17The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
10.5K
相关概念视频
01:07Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
01:16Necrosis
4.1K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.1K
01:15Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K