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Updated: Aug 2, 2026

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精确和可控制的合成基于聚合物模板的超稳定的金纳米粒子,用于miRNA检测

Longwei Xiang1, Tong Li1, Guanhe Fang1

  • 1State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China. thy@xmu.edu.cn.

Chemical communications (Cambridge, England)
|February 7, 2025
PubMed
概括

研究人员使用一种新的核心外结构创建了超稳定的金纳米粒子. 这些纳米颗粒能够精确地检测微RNA,从而有效地查瘤细胞.

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...