基于心电图的脉冲波速度系统,用于对动脉硬度进行非封闭性评估
T Corina Margain1, Emily Powell1, Alexandra Clark2
1Biomedical Engineering Department, Translational Cardiovascular Imaging Group, The University of Texas at Austin, Austin, TX, United States.
Frontiers in cardiovascular medicine
|February 7, 2025
概括
这项研究提出了一种新的,低成本的系统,用于测量动脉硬性,使用心电图和胸膜图. 新方法为心血管风险分层提供了可访问和可靠的脉冲波速度评估.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 医学诊断 医学诊断 医学诊断
背景情况:
- 动脉硬是血管衰老和病理学的关键指标.
- 目前用于测量中枢动脉硬度的方法,如动脉脉冲波速率 (PWV),昂贵且需要专业知识,限制了临床使用.
- 需要易于使用,具有成本效益的工具来评估动脉硬性.
研究的目的:
- 引入和评估一种用于测量脉冲波速率 (PWV) 的新型半封闭式和非封闭式系统.
- 为了评估这个新系统的可行性和准确性,使用单个股骨压力袖口的心电图 (PCG) 和胸膜图 (PPG) 来评估这一新系统的可行性和准确性.
- 以PCG为基础的PWV测量与已确定的参考值和超声波测量的延展性进行比较.
主要方法:
- 开发了一种半封闭式 (带-带PWV) 和非封闭式 (带-脚PWV) 测量系统,利用PCG和PPG信号.
- 为这项研究招募了63名志愿者.
- 基于PCG的PWV测量与文献参考值进行比较,并通过超声波延展性评估验证了结果.
主要成果:
- 在基于PCG的PWV测量和年龄之间观察到强烈的相关性 (PWV心肌-股骨:r2=0.45;PWV心肌-脚:r2=0.28,p<0.05).
- 超声波延展性证实了PCG方法在反映中枢动脉硬性的可靠性.
- 测试重复测试的高可靠性 (ICC:0.750.90) 表明该方法具有强大的可重复性.
结论:
- 开发的低成本,半封闭和非封闭的PWV测量系统是可行的和准确的.
- 这种方法提高了动脉硬性评估的可访问性.
- 该系统有可能在临床环境中改善心血管风险分层.
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