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怀孕期间大气颗粒物污染与中国过早分娩之间的关联:元分析

Bingbing Guo¹, Xinye Jiang¹

¹Wuxi Maternity and Child Health Care Hospital, Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu, China.

Frontiers in public health

|February 7, 2025

概括

在中国,孕妇在怀孕期间暴露于颗粒物 (PM2.5和PM10) 与早产风险略有增加有关,特别是在第二和第三季度. 需要进一步的研究来证实这种微弱的关联.

科学领域:

环境健康环境健康
生殖流行病学生殖流行病学
公共卫生公共卫生

背景情况:

孕妇在怀孕期间暴露于室外空气污染,特别是颗粒物 (PM),是一个越来越令人担忧的问题.
颗粒物对中国早产产生的影响,这是一个具有独特污染条件的地区,尚不清楚.
关于母亲暴露于颗粒物物和早产之间的关系的现有研究产生了不一致的结果.

研究的目的:

评估在怀孕期间暴露于大气颗粒物 (PM2.5和PM10) 与中国早产之间的相关性.
通过元分析来综合现有证据,以澄清关系.

主要方法:

在中文 (CNKI,Wanfangdata) 和英语 (PubMed,Web of Science,Embase) 数据库中进行了全面的文献搜索.
包括调查母亲在怀孕期间暴露于颗粒物和中国早产的研究.
使用Stata12.0软件对29项涉及900多万参与者的研究数据进行了元分析.

主要成果:

孕妇在怀孕中期 (OR=1.03),怀孕后期 (OR=1.03) 和整个怀孕期间 (OR=1.07) 暴露于PM2.5显示出与早产风险增加的统计学意义上的关联.
在怀孕期间暴露于PM10也与早产风险略有增加有关 (OR=1.04).
对于其他暴露时间,没有发现显著的相关性.

结论:

在中国,在怀孕的第二个和第三个季度暴露于颗粒物与早产风险的小但显著增加有关.
观察到的关联相对较弱,潜在的混因素可能会影响结果.
建议进行进一步的深入研究,以阐明颗粒物暴露与早产以及其他不良妊娠结果之间的关系.

关键词:

大气中的颗粒物.问题污染污染这是一个元分析.怀孕怀孕怀孕怀孕怀孕过早出生的早产.

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