尽管显然使用相同的施奈德药理动力学模型,但目标控制输液的不同行为:一项观察性体外研究
Martin Soehle1, Andreas Wolter1, Marcus Thudium1
1From the Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Germany (MS, AW, MT, SF, MC).
European journal of anaesthesiology and intensive care
|February 7, 2025
概括
不同的目标控制输液 (TCI) 显示出初始propofol玻尿酸剂量的变化,即使使用相同的药理动力学模型. 这些与平衡速率常数 (ke0) 相关的差异可能会影响麻醉诱导.
科学领域:
- 麻醉学 麻醉学
- 药理动力学 药理动力学
- 医疗器械技术 医疗器械技术
背景情况:
- 目标控制输液 (TCI) 用于通过初始玻尿酸剂量快速达到目标药物度.
- TCI算法的变化可能会影响药物输送的准确性.
研究的目的:
- 通过使用相同的药理动力学模型,研究各种TCI输送的初始propofol玻尿酸剂量的潜在差异.
- 确定不同算法实现对药物输送的影响.
主要方法:
- 通过使用德国大学医院的实验室数据进行了一项观察性研究.
- 四个TCI (Perfusor® Space®,Injectomat TIVA Agilia®,Alaris® PK,Syramed® μSP6000) 被编程使用了施奈德模型.
- 在13名具有不同人口特征的虚拟患者中评估了的性能,测量了初始的普罗波福尔剂量.
主要成果:
- 在一些模拟患者中,观察到醇玻尿酸剂量的轻微变化.
- 在其他模拟患者中,特别是在肥胖男性 (72.0 ± 1.0 mg与111.9 ± 1.2 mg相比,P < 0.001) 中,在初始剂量中发现了显著的差异.
- 均衡速率常数 (ke0) 的差异被确定为一个贡献因素.
结论:
- 在TCI制造商之间,由于施奈德的药理动力学模型的实施方式的差异,在初始的propofol玻尿酸输送中存在差异.
- 麻醉师必须意识到这些制造商之间的差异,以确保在麻醉诱导期间准确的普罗波福尔剂量和患者安全.
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