在中风后,大脑受损区域内的有效连接性发生变化和认知障碍
Jing Zhang1, Hui Tang1, Lijun Zuo2
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191 China.
Cognitive neurodynamics
|February 7, 2025
概括
脑卒中后认知障碍 (PSCI) 与大脑网络连接的改变有关. 这项研究揭示了特定大脑区域的损伤如何影响功能网络,从而导致中风后的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 认知科学 认知科学
背景情况:
- 脑卒中后认知障碍 (PSCI) 是由脑损伤引起的网络功能障碍引起的.
- 在功能网络和PSCI中受损区域的确切作用尚未完全理解.
研究的目的:
- 为了研究基底脉梗塞对功能性大脑网络的影响及其与PSCI的关联.
- 探索PSCI患者的结构和功能连接性改变.
主要方法:
- 招募了35名初次中风患者,其中包括基底腺心脏病发作和PSCI,以及29名健康对照 (HC).
- 使用T1加权成像用于灰质体积 (GMV) 分析和静止状态fMRI用于波形ALFF和动态功能连接 (dFC) 分析.
- 检查了异常dFC网络中的有效连接性及其与认知功能的相关性.
主要成果:
- 患者在双边罗兰迪克部 (ROL) 呈现降低的GMV,在右脑前 (PCUN) 和左脑_9 (CER9) 呈现异常的波形-ALFF.
- 一个异常的dFC网络播种在左侧的ROL中,涉及ROL,PCUN,CER9,STG和PHG,在PSCI和HC组之间存在显著差异.
- 改变有效连接,特别是结构受损和自发活跃区域之间的连接,与认知障碍相关.
结论:
- 损伤的大脑区域内有效连接的改变有助于PSCI的认知缺陷.
- 基底脉梗塞破坏了广泛的功能网络,通过改变的连接模式影响认知领域.
相关概念视频
Association Areas of the Cortex
10.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
10.2K
Higher Mental Functions of the Brain: Language
6.0K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
6.0K
Prosopagnosia
1.3K
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
1.3K
Role of Cerebellum and Prefrontal Cortex in Memory
1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Dementia l: Introduction
35
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
35
Secondary Spinal Cord Injury llI: Pathophysiology
52
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
52


