在急性SARS-CoV-2感染期间的病毒负担和疾病严重程度预测了持续的长期COVID症状
Elisabeth Brandstetter Figueroa1,2, Anne E P Frosch1,3, Kristina S Burrack1,4
1Division of Infectious Diseases, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
Open forum infectious diseases
|February 7, 2025
概括
长期COVID,严重急性呼吸系统综合征冠状病毒2的并发症,在急性疾病期间更有可能发生在具有可检测病毒抗原或需要氧气的患者中. 持续的症状会影响日常功能.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 长期COVID是严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染的常见并发症.
- 长期COVID的流行率和预测因素仍然没有很好的特征.
- 了解长期COVID对于公共卫生管理至关重要.
研究的目的:
- 为了前性地研究长期COVID在成年人中的患病率和预测因素.
- 确定与长期COVID相关的人口,临床和实验室特征.
- 描述持久症状的个体的症状和功能限制.
主要方法:
- 对患有急性COVID-19的成年人 (≥18岁) 进行前性研究.
- 从城市安全网医院和诊所收集的数据 (2020年7月 - 2022年12月).
- 后勤回归用于评估与长期COVID状态 (症状持续≥9个月) 的关联.
主要成果:
- 在222名参与者中,有162人9个月后已知康复状态.
- 可检测的核体抗原 (aOR 3.0) 和补充氧气需求 (aOR 3.6) 与长期COVID相关.
- 41%的人经历了持续的症状,中枢神经系统和心理症状是最常见的,导致57%的功能限制.
结论:
- 随着急性疾病的严重程度降低,长期COVID的患病率可能会降低.
- 高病毒负担和延长复制仍然可能发生,即使在接种疫苗后.
- 准确的长期COVID的特征是至关重要的,因为病毒的进化会改变急性疾病的表现.
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