在COVID-19后综合征中慢性疲劳和头痛:放射学和临床评估
Gonçalo G Almeida1,2, Saide Alkan3,4, Robert Hoepner5
1Department of Radiology, Kantonsspital Baden, Baden, Switzerland.
Frontiers in neurology
|February 7, 2025
概括
长期COVID患者经常有脑部病变,但这些T2高强度白质病变与疲劳或头痛无关. 需要进一步的研究来了解COVID-19后综合征症状和MRI发现.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19综合征 (长期COVID) 呈现出持续的症状,如疲劳和头痛.
- 在一些长期COVID患者中,在MRI上观察到T2高强度白质病变.
- 这些病变与特定的长期COVID症状之间的关系尚不清楚.
研究的目的:
- 调查脑脊髓MRI上T2高强度白质病变与COVID-19后综合征患者疲劳和头痛症状之间的相关性.
主要方法:
- 对96名怀疑患有COVID-19后综合征的患者进行了回顾性分析.
- 自我报告问卷评估了疲劳,情绪健康和白天的嗜睡.
- 独立的神经辐射学家对T2高强度病变的评分在脑和脊柱MRI上.
主要成果:
- 研究队列 (平均年龄46岁) 主要由女性 (73%) 组成.
- 报告了疲劳 (90%),头痛 (57%) 和睡眠障碍 (51%) 的高患病率.
- 大脑MRI显示72%的患者出现T2高强度病变,但与疲劳或头痛症状没有显著的相关性 (p > 0.178).
结论:
- 在COVID-19后综合征患者中,T2高强度白质病变很常见,但与疲劳或头痛无关.
- 这些MRI发现可能无法直接解释这些长期COVID症状的主观体验.
- 需要进行更大规模的研究来探索潜在的混因素以及MRI发现与长期COVID之间的复杂关系.
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