作为预防儿童化疗诱导吐的组合疗法:分析
Yanshuo Shi1,2, Yuanyuan Yue1,2, Yue Zhang1
1Department of Pharmacy, Hebei General Hospital, Shijiazhuang, China.
Frontiers in pharmacology
|February 7, 2025
概括
与5-HT3受体对抗剂 (5-HT3RA) 结合的普雷皮坦能有效地预防儿童的化疗诱导吐. 与单独使用5-HT3RA相比,这种组合疗法显示出更高的疗效,不增加不良事件.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 化疗诱导吐 (CINV) 是儿童癌症护理的一个重大挑战.
- 5西胺3受体对抗剂 (5-HT3RA) 是标准的抗治疗方法.
- 添加神经素-1受体抗剂,如福萨普雷皮坦,可以改善CINV控制.
研究的目的:
- 系统地评估在儿童癌症患者中CINV治疗中与5-HT3RA (含或不含德甲) 结合的福萨普雷皮坦的临床疗效和安全性.
- 为了比较这种组合疗法与单独的5-HT3RA (带有或没有德甲).
主要方法:
- 对随机对照试验 (RCT) 和队列研究进行了元分析.
- 搜索的数据库包括PubMed,Embase,Cochrane图书馆,CNKI,万芳和VIP (直到2024年4月).
- 使用Rev Man 5.3软件提取和分析数据.
主要成果:
- 分析了包括731名患者在内的7项试验.
- 福萨普雷皮坦和5-HT3RA的组合在CINV的急性,延迟和整体阶段显示出明显更高的完全响应率.
- 亚组分析表明,随着福萨普雷皮坦 (fosaprepitant) 组合,救援药物的需求减少. 药物不良反应的发生率在各组之间是相似的.
结论:
- 与5-HT3RA (带有或没有德甲) 结合的普雷皮坦在预防儿科癌症患者的化疗诱导吐方面比单独的5-HT3RA更有效.
- 组合疗法表现出与标准的5-HT3RA疗法相比较的安全性.
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