在重症患者中补充β-基β-甲基丁酸盐:随机对照试验的系统审查和元分析
Yu Ren1, Ya-Bei Gao2, Da-Xing Yu3
1Department of Emergency, Fuxing Hospital of Capital Medical University, Beijing, China.
Frontiers in nutrition
|February 7, 2025
概括
补充beta-hydroxy-beta-methylbutyrate (HMB) 并没有改善危急病患者的死亡率或临床结果. 需要进一步的研究来确定这个人群的最佳HMB策略.
科学领域:
- 临床营养学 临床营养学
- 临界护理医学 临界护理医学
- 代谢研究研究 代谢研究
背景情况:
- 贝塔-基-贝塔-甲基酸盐 (HMB) 以其恢复肌肉的特性而闻名.
- 在重症患者群体中HMB的疗效仍然不完全理解.
- 这项研究系统地审查和分析了HMB对重症患者的影响.
研究的目的:
- 评估Beta-hydroxy-beta-methylbutyrate (HMB) 补充剂在严重病情的成年患者中的有效性.
- 确定HMB对这一脆弱群体死亡率和其他关键临床结果的影响.
- 确定可能导致HMB效应异质性的因素.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane等) 进行了系统的文献搜索. ) 的情况.
- 九个随机对照试验 (RCT) 将HMB与对照组进行比较,被纳入了元分析.
- 主要结局是死亡率,次要结局包括机械通风持续时间,ICU/住院时间和身体组成变化.
主要成果:
- 在HMB和对照组之间没有观察到死亡率的显著差异 (RR = 0.96;95% CI,0.44-2.08;P = 0.92).
- HMB并没有显著改变机械通风,ICU住院或住院的持续时间.
- 体重,BMI,四头肌厚度,骨肌面积和肌肉损失的变化在各组之间是相似的.
结论:
- 贝塔-基-贝塔-甲基酸盐 (HMB) 似乎没有改善危急病患者的死亡率或临床结果.
- 研究中的HMB管理策略的变化可能会影响结果.
- 研究结果表明,需要精细的研究设计来探索HMB在重症监护机构的临床实用性.
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