免疫检查点抑制剂对生育的影响:一篇评论
Iram Shabir1, Christina Foster1
1Department of Hematology/Oncology, McFarland Clinic Ames, Iowa, USA.
Reviews on recent clinical trials
|February 7, 2025
概括
免疫检查点抑制剂可以影响生育能力和性健康. 对接受免疫治疗的癌症患者来说,讨论生殖风险和保存选择至关重要.
科学领域:
- 在瘤学瘤学.
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 治疗是癌症治疗的基石.
- ICI治疗可能会导致免疫中介的不良事件,影响多个器官,包括生殖系统.
- 关于ICI对生育能力,性健康和怀孕结果的影响的临床数据有限.
研究的目的:
- 审查免疫治疗对男性和女性生育能力的影响.
- 检查免疫治疗对性健康的影响.
- 强调生育保护和癌症患者咨询的重要性.
主要方法:
- 关于免疫疗法的生殖和性副作用研究的文献综述.
- 对ICI治疗的患者生育能力和性健康结果的临床数据的分析.
- 关于与癌症治疗相关的生殖功能障碍管理信息的综合.
主要成果:
- ICI治疗与性功能障碍有关,包括性欲下降,勃起功能障碍和阴道滑减少.
- 接受免疫治疗的患者可能会经历心理困扰,如焦虑和抑郁,如果不充分咨询生殖风险.
- 想要生育的患者需要全面的咨询和积极的管理策略.
结论:
- 解决ICI治疗的生殖后果是必不可少的.
- 传播有关新型治疗方法和预防生殖副作用的预防措施的知识至关重要.
- 应向受影响的个体提供生育能力保护选择和激素替代疗法.
相关概念视频
02:34Inhibition of Cdk Activity
4.6K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.6K
01:27Tumor Immunotherapy
464
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
464
01:23Infertility in Males
235
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
235