急性胰腺炎患者早期出院后死亡率增加
Line Davidsen1,2, Cecilie S Knoph1,2, Mathias E Cook1,2
1Centre for Pancreatic Diseases and Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
United European gastroenterology journal
|February 7, 2025
概括
经过急性胰腺炎康复的患者在出院后90天内面临高死亡风险,尽管住院死亡率有所改善. 这种高死亡风险持续长达五年,强调需要持续监测和护理.
科学领域:
- 胃肠病学和肝病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 急性胰腺炎带来了显著的死亡风险,特别是在出院后的早期.
- 缺乏关于出院后死亡率的综合性基于人口的研究.
- 了解长期结果对于患者管理至关重要.
研究的目的:
- 调查急性胰腺炎患者的住院和出院后死亡率.
- 分析15年死亡率的时间趋势.
- 确定与急性胰腺炎相关的风险因素和结果.
主要方法:
- 全国丹麦对急性胰腺炎 (2002-2017) 后出院的成年人的队列研究.
- 从一般人群中匹配对照组 (1:5比率).
- 考克斯回归分析以评估出院后90天,1,2年和5年的全因死亡率,经过对共变量进行调整.
主要成果:
- 在28759名急性胰腺炎患者中,3.3%在医院死亡.
- 90天后出院后的死亡率为患者的5.0%,对照组的0.55% (aHR 7.62).
- 死亡率升高的风险持续长达5年 (aHR1.85);住院死亡率下降,但出院后的风险保持稳定.
结论:
- 由于急性胰腺炎的住院死亡率有所下降.
- 出院后的死亡风险仍然很高,特别是在前90天内.
- 胃肠道和心血管疾病是出院后早期死亡的主要原因.
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