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Updated: May 29, 2025

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激活AMPK可以改善由于mtDNA枯竭而导致的病态表型

Gustavo Carvalho1, Tran V H Nguyen1, Bruno Repolês1

  • 1Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.

The FEBS journal
|February 7, 2025
PubMed
概括

AMP激活蛋白激酶 (AMPK) 激活发生在线粒体功能障碍的早期,甚至在能量水平下降之前. 用A-769662刺激AMPK改善了线粒体功能,并在疾病模型中部分恢复了DNA水平.

关键词:
这就是AMPKK.通过AMP激活的蛋白激酶.线粒体DNA的枯竭 线粒体DNA的枯竭聚合酶的时间

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