老年人群中阿哈拉西亚的口腔内镜肌切除术:系统性审查和元分析
Umar Hayat1, Faisal Kamal2, Adil Memon3
1Department of Internal Medicine, Geisinger Wyoming Valley Medical Center, Wilkes-Barre.
Journal of clinical gastroenterology
|February 7, 2025
概括
口腔内镜肌切除术 (POEM) 是对老年患者的秋拉西亚的一种安全有效的治疗方法. 这次元分析发现,与年轻患者相比,成功率或不良事件没有显著差异.
科学领域:
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
- 老年医学 老年医学
背景情况:
- 阿哈拉西亚是一种罕见的食道运动障碍.
- 老年患者经常有并发症,这引发了对治疗安全性的担忧.
- 关于口腔内镜肌切除术 (POEM) 在患有阿喀拉西亚的老年人中可行性的证据存在矛盾.
研究的目的:
- 为了评估POEM在老年患者中治疗阿喀拉西亚的安全性和有效性.
- 为了比较不同年龄组之间的POEM结果 (≥75与<75岁和≥65与<65岁).
主要方法:
- 一项对已发表的研究进行的元分析,比较了老年患者与年轻患者的阿喀拉西亚的POEM.
- 主要结局包括技术和临床成功率.
- 第二次结果是不良事件的发生率.
- 随机效应模型被用于计算聚合赔率比率.
主要成果:
- 分析了6项涉及290名75岁以上和2290名75岁以下患者的研究.
- 聚合的技术成功率为98.66% (≥75) 和97.81% (<75).
- 综合的临床成功率为99.01% (≥75) 和97.97% (<75).
- 在年龄组之间没有观察到技术成功,临床成功或不良事件的显著差异.
结论:
- POEM是一种可行且安全的治疗选择,用于老年患者的.
- 年龄不是影响POEM结果的重要因素,在治疗阿喀拉西亚.
- 该程序的安全性和有效性延伸到老年人,即使有并发症.
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