梅西林对抗多种耐药性Shigella sonnei和Shigella flexneri的活性
Aleksandra Stefanovic1,2, Leah Gowland1, Gordon Ritchie1,2
1Division of Medical Microbiology and Virology, St. Paul's Hospital, Providence Health Care, Vancouver, British Columbia, Canada.
Microbiology spectrum
|February 7, 2025
概括
皮夫梅基利纳姆对抗多药耐药西格拉菌具有有希望的活性,具有有利的敏感性测试结果,并且没有检测到耐药基因. 需要进一步的研究,以制定用于治疗西格拉菌感染的临床指南.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 西格拉菌中出现的抗生素耐药性限制了治疗选择.
- 世界卫生组织推Pivmecillinam治疗西格拉菌感染,但其在北美的疗效尚未得到充分研究.
- 缺乏针对西格拉菌的梅西林安的标准化敏感性测试.
研究的目的:
- 调查梅西林安在体外对抗多药耐药西格拉菌的活性.
- 为了确定在Shigella分离物中抗美西林抗性的潜在遗传机制.
- 突出了在Shigella中测试梅西林纳姆敏感性的标准化临床断点的需要.
主要方法:
- 现型敏感性测试 (稀释,圆盘扩散) 在95个Shigella分离物上进行.
- 全基因组测序被用来识别抗美西林胺耐药性的遗传决定因素.
- 分析了最小抑制度 (MIC) 和区域直径.
主要成果:
- 观察到有利的梅西林胺敏感性,MIC50和MIC90值分别为1和2μg/mL.
- 所有的隔离物体都通过光盘扩散显示了敏感区直径 (≥15毫米).
- 在整个基因组中没有发现已知的抗美西林胺突变,包括cysB.
结论:
- 梅西林在体外表现出良好的活性,对抗多药耐药的西格拉菌.
- 缺乏抗药性标志物表明,pivmecillinam可能是一个可行的治疗选择.
- 标准化易感性测试方法和临床断点对于指导Pivmecillinam治疗Shigella感染至关重要.
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