补充维生素D可以改善幼儿的体质:两中心试点研究
Yuko Sakamoto1,2,3, Makoto Kamegaya4, Takashi Saisu4
1Department of Orthopaedics, Juntendo University Nerima Hospital, 3-1-1 Takanodai, Nerima-ku, Tokyo, 117-8421, Japan. u-sakamo@juntendo.ac.jp.
Journal of bone and mineral metabolism
|February 7, 2025
概括
低剂量维生素D (VitD) 补充剂加速了幼儿的体质改善. 这表明真可能表明VitD缺乏,特别是在补充剂实践较低的地区.
科学领域:
- 儿科整形外科 儿科整形外科
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 基努瓦鲁姆 (曲的腿) 在幼儿时代自然纠正,但可以持续存在.
- 持续存在的 genu varum 可能表明维生素 D (VitD) 缺乏.
- 在日本,VitD缺乏症很普遍,补充剂的比例很低.
研究的目的:
- 评估低剂量维生素D补充剂对幼儿真实体质改善的影响.
- 为了研究VitD缺乏症和持续性热血病之间的关系.
主要方法:
- 对90名幼儿 (10至30个月) 进行了回顾性研究,他们患有 genu varum.
- 补充剂组 (400 IU/day VitD) 与非补充剂组的比较.
- 放射测量 (TFA,MDA,MMA) 在基线,6个月和12个月.
主要成果:
- 两组都出现了改善,但VitD组的TFA,MDA和MMA的减少明显更大.
- 在紫外线暴露较高的季节,改善更为明显.
- 低剂量VitD补充剂增强了下肢对齐.
结论:
- 低剂量VitD补充剂可以加快幼儿的 genu varum 校正.
- 基努瓦鲁姆可能是维生素D缺乏症的临床症状.
- 建议进一步进行随机对照试验.
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