单个超声驱动微气泡的应力-应变分析用于粘性弹性外的特征表征
Charlotte L Nawijn1, Sander Spiekhout2, Jason Voorneveld2
1Physics of Fluids group, Technical Medical (TechMed) Center, Max Planck Center Twente for Complex Fluid Dynamics, University of Twente, Enschede, the Netherlands.
The Journal of the Acoustical Society of America
|February 7, 2025
概括
一种新的压力-应变方法准确地描述了微泡的外,这对于超声波成像和治疗至关重要. 这种技术为微泡的粘弹性特性提供了详细的见解,增强了它们的临床应用.
科学领域:
- 生物医学工程 生物医学工程
- 声学 声学 在声学方面
- 材料科学 材料科学 材料科学
背景情况:
- 微气泡对于超声波成像和治疗至关重要,其性能与外粘弹性有关.
- 现有的表征方法依赖于有关骨质学的假设.
- 了解微气泡的非线性反应是优化它们使用的关键.
研究的目的:
- 引入一种新的应力-应变方法,用于描述单个微气泡的粘弹性外.
- 尽量减少关于外风学的假设,专注于可分离的粘性和弹性贡献.
- 验证该方法并将其应用于量化脂外微气泡的外特性.
主要方法:
- 使用高频超声波散射来测量微泡的振荡.
- 精确确定声学驱动压力和频率.
- 在曲和破裂的系统中采用表面张力适配程序,以管理实验不确定性.
主要成果:
- 该方法通过模拟进行了验证.
- 实验描述了275个个别的微气泡.
- 在 (0.49 ± 0.10) N m-1 确定外弹性,在 (28.7 ± 3.94) mN m-1.1 确定初始表面张力.
结论:
- 拟议的应力-应变方法提供了一种强大的方法,以最小的假设来表征微泡外的粘性弹性.
- 这种技术提供了有关个体微气泡动态的宝贵数据.
- 这些发现为描述微泡外中的粘性消散机制铺平了道路,推动了超声波应用.
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