在患有 osteogenesis imperfecta 的儿童中发生突发过程
Clara Sandibel Garcete Delvalle1, M Joaquín De Nova García2, María Rosa Mourelle Martínez2
1Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain. cgarcete@ucm.es.
Calcified tissue international
|February 7, 2025
概括
用于儿童骨质变生不完善 (OI) 的双酸盐 (BPs) 可能会延迟牙发育,根部再吸收和永久性突发. 虽然这些影响往往是微妙的,但强调了监测OI患者接受BP治疗的牙健康的重要性.
科学领域:
- 儿科牙科 儿科牙科
- 矯正牙科 矯正牙科是一種矯正牙科.
- 遗传学和遗传性疾病
背景情况:
- 骨质变生不完美 (Osteogenesis Imperfecta,简称OI) 是一种导致骨脆弱的遗传疾病.
- 双酸盐 (BPs) 用于增加OI儿童的骨密度.
- 乙是抗吸收剂,可以影响涉及骨质细胞的生理过程,例如牙喷发.
研究的目的:
- 研究双酸盐 (BP) 治疗对患有骨质发育不完善 (OI) 的儿童爆发过程的影响.
- 为了比较牙发育,初级牙再吸收,以及在儿童中首次永久性牙喷发OI在BP与对照组.
- 分析累积血压剂量与牙发育中的潜在延迟之间的相关性.
主要方法:
- 追溯分析了BP上34名OI儿童和367名健康儿童的全景放射图.
- 使用德米尔吉安方法来评估永久牙发育和哈维科方法进行一次性牙根再吸收.
- 测量了第一个永久的膜喷发,并计算了累计的BP剂量.
主要成果:
- 在BP上OI的儿童表现出牙发育延迟 (0.95分) 和初级牙脱皮 (1.311.66年).
- 观察到主要牙根吸收的显著延迟 (总体11.8%,根据牙类型而异).
- 观察到第一个永久性牙 (0.31年) 的延迟膜喷发,累计高血压剂量 (>2000) 的患者的延迟更大.
结论:
- 在患有OI的儿童中,双酸盐治疗可能会导致牙发育和牙喷发的临床上微妙但统计学上显著的延迟.
- 初级牙根再吸收也受到BP治疗的影响,这表明对牙有更广泛的影响.
- 监测牙发育和牙喷发对于接受双酸盐治疗的OI儿童至关重要,特别是考虑到累积剂量.
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