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Updated: May 29, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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非编码RNA在心血管病理生理学的新兴作用

Malak Abbas¹, Amadou Gaye²

¹National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.

American journal of physiology. Heart and circulatory physiology

|February 7, 2025

概括

非编码RNAs (ncRNAs) 是心血管疾病 (CVD) 发展和治疗的关键参与者. 研究强调了它们作为高血压和心脏病发作等疾病的生物标志物和治疗点的潜力.

科学领域:

分子生物学分子生物学
遗传学遗传学是一个
心血管医学心血管医学

背景情况:

非编码RNAs (ncRNAs) 是参与心血管疾病 (CVD) 发病的细胞过程的关键调节者.
特定的ncRNAs,包括microRNAs (miRNAs),长非编码RNAs (lncRNAs) 和piwi相互作用RNAs (piRNAs),显著影响基因表达,炎症和纤维化.

研究的目的:

综合审查各种ncRNA在心血管疾病的发展和治疗中的多方面的作用.
探索ncRNA和细胞外囊泡 (EV) 在心血管医学中的诊断和治疗潜力.

主要方法:

对心血管疾病中ncRNAs (miRNA, lncRNA, piRNA, siRNA, circRNA,囊泡相关RNAs) 的系统文献综述.
对ncRNA参与基因表达,炎症和纤维化等关键细胞过程的分析.
检查ncRNA对特定心血管疾病 (高血压,动脉样硬化,心肌梗塞) 的贡献以及EVs的作用.

主要成果:

ncRNAs是细胞过程的完整调节者,对心血管疾病至关重要.
miRNAs,lncRNAs和piRNAs特别涉及高血压,动脉样硬化和心肌梗塞.
细胞外囊泡 (EVs) 在细胞间通信中发挥作用,并为心血管健康提供治疗潜力.

结论:

ncRNAs代表了有前途的诊断生物标志物和心血管疾病的治疗点.
进一步研究基于ncRNA的疗法,包括先进的输送系统和个性化药物,对于改善心血管结果至关重要.
在心血管健康中EVs的治疗潜力需要继续调查.

关键词:

在CVD中,CVD是非常重要的.没有编码的RNA.

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