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在PCI手术后患有管功能障碍的患者的尿代谢分析

Wenwen Huang¹, Xinxin Chen¹, Xiaoyan Xu¹

¹Department of Nephrology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

International urology and nephrology

|February 7, 2025

概括

研究人员确定了16种泌尿代谢物和11种代谢途径,包括氨酸生物合成,作为通过皮肤冠状动脉干预 (PCI) 检测管功能障碍的潜在生物标志物. 这些发现有助于诊断对比诱导性病 (CIN).

科学领域:

腎臟病學 (nephrology) 是一種醫學.
心脏病学心脏病学
代谢学代谢学代谢学

背景情况:

穿皮冠状动脉干预 (PCI) 可能导致管功能障碍,这种并发症被称为对比诱导性病 (CIN).
早期发现CIN对于患者的管理和预防进一步的损伤至关重要.

研究的目的:

在PCI后确定管功能障碍的尿代谢标志物.
探索参与CIN发展的代谢途径.

主要方法:

在PCI前和PCI后6小时,从50名患者收集了尿液样本.
液态染色学-质谱学 (LC-MS) 用于分析代谢概况.
使用了多变量统计分析 (PCA,OPLS-DA) 和途径分析 (MetaboAnalyst 5.0).

主要成果:

确定了16种不同的尿代谢物,包括α1-MG,NAG和Cys-C,这些代谢物在PCI后显著增加.
途径分析涉及11个代谢途径,其中氨酸生物合成和氨酸,酸盐和谷氨酸代谢与管管功能障碍最相关.
代谢物如L-ornithine,油酸胺和胆固醇酸是16种已确定的代谢物之一.

结论:

对尿样的LC-MS分析确定了PCI后诊断管功能障碍的潜在生物标志物.
氨酸生物合成和氨酸,酸盐和谷氨酸代谢途径在CIN的发病过程中起着重要作用.

关键词:

代谢学代谢学代谢学通过皮肤进行冠状动脉干预.管功能障碍管功能障碍

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