在COVID-19后急性阶段的儿科胃肠道结果
Dazheng Zhang1,2, Ronen Stein3,4, Yiwen Lu1,5
1The Center for Health AI and Synthesis of Evidence, University of Pennsylvania, Philadelphia.
JAMA network open
|February 7, 2025
概括
患有COVID-19的儿童和青少年在后急性和慢性阶段都有更高的胃肠道 (GI) 症状和疾病的风险. 感染后,持续的胃肠道问题更为常见,这凸显了临床意识的必要性.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 儿童群体中COVID-19的长期胃肠道 (GI) 影响尚不清楚.
- 在儿童感染SARS-CoV-2后,调查后急性和慢性胃肠道结果至关重要.
研究的目的:
- 评估SARS-CoV-2感染后的后急性 (28-179天) 和慢性 (180-729天) 阶段儿童和青少年胃肠道症状和疾病的风险.
- 为了比较COVID-19记录的和没有记录的儿科患者之间的GI结果.
主要方法:
- 这是一项回顾性队列研究,涉及29个美国医疗机构的150多万儿科患者.
- 通过阳性测试结果或诊断码确定了SARS-CoV-2感染.
- 用诊断代码识别了胃肠道症状和疾病;使用分层Poisson回归分析风险.
主要成果:
- 患有COVID-19的儿科患者在后急性阶段 (ARR,1.25) 和慢性阶段 (ARR,1.28) 增加了胃肠道症状/疾病的风险.
- 具体来说,COVID-19阳性儿童的腹痛风险在后急性 (ARR,1.14) 和慢性 (ARR,1.24) 阶段都较高.
- 该队列包括413,455名有SARS-CoV-2感染记录的患者和1,163,478名没有感染的患者.
结论:
- 记录的SARS-CoV-2感染与儿童和青少年的胃肠道症状和疾病风险较高有关.
- 临床医生应该意识到COVID-19后儿科患者可能出现持续的胃肠道问题.
- 这些发现强调了监测COVID-19感染后儿童的胃肠道健康的重要性.
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