免疫媒介炎症疾病患者的COVID后的一般健康症状
Natasja van de Pol1, C Janneke van der Woude1, Marijn Vis2
1Departments of Gastroenterology and Hepatology.
European journal of gastroenterology & hepatology
|February 7, 2025
概括
患有免疫媒介性炎症性疾病 (IMIDs) 的患者曾经感染过SARS-CoV-2,与没有感染的患者相比,他们报告了更多的一般健康症状,特别是疲劳. 需要进一步的研究来了解IMID患者的这些COVID后症状.
科学领域:
- 免疫学和传染病的研究
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 皮肤病学 皮肤病学
背景情况:
- 后COVID,以SARS-CoV-2感染后的持续症状为特征,影响各种患者群体.
- 免疫媒介性炎症性疾病 (IMIDs) 涉及复杂的免疫系统失调.
- 感染SARS-CoV-2对IMID患者的影响需要彻底调查.
研究的目的:
- 为了评估SARS-CoV-2感染后IMID患者的一般健康症状的患病率.
- 为了比较IMID患者与没有SARS-CoV-2感染史之间的症状负担.
- 在IMID人群中识别与COVID后症状相关的风险因素.
主要方法:
- 一个在线问卷被管理到IMID患者接受全身治疗跨多个部门.
- 在有或没有先前感染SARS-CoV-2的患者之间比较了一般健康症状.
- 多变量逻辑回归分析调整了与疾病相关的和COVID后的风险因素;评估了自我报告的症状归因于感染.
主要成果:
- 在1518名被纳入的患者中,58%报告了之前的SARS-CoV-2感染;13.9%将症状归因于它.
- 患有先前感染的患者表现出更高的症状流行率 (56.2%对43.9%) 和疲劳 (42%对32%) (P<0.001).
- 调整后的分析证实了先前感染与症状 (OR: 1.53) 和疲劳 (OR: 1.31) 相关;COVID-19的严重程度与症状相关.
结论:
- 患有SARS-CoV-2感染史的IMID患者报告了明显更多的一般健康症状,特别是疲劳.
- 在IMID患者中驱动这些后COVID症状的潜在机制需要进一步调查.
- 了解这些症状可以为IMID患者和普通人群提供有关COVID后病原学的见解.
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