美国成年人中C-反应蛋白和慢性疼痛之间的关联:全国性的横截面研究
Chunsheng Huang1, Qizhen Tong2,3, Qiaoling Tong4
1Department of Anesthesiology, Ningbo Medical Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, Zhejiang, China.
PloS one
|February 7, 2025
概括
升高的C-反应蛋白 (CRP) 水平与美国成年人的慢性疼痛有显著的关联. 较高的CRP水平表明经历慢性疼痛的风险增加,这表明炎症和持续疼痛之间存在潜在联系.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 生物医学科学 生物医学科学
背景情况:
- 慢性疼痛是美国的主要公共卫生问题.
- 了解它的特征对于开发有效的干预措施至关重要.
- 这项研究调查了慢性疼痛的患病率及其与C反应性蛋白 (CRP) 水平的关联.
研究的目的:
- 为了确定美国成年人口中慢性疼痛的患病率.
- 检查慢性疼痛与C反应蛋白 (CRP) 水平之间的关联.
- 探索CRP和慢性疼痛之间的剂量反应关系.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据进行横截面研究.
- 权重后勤回归分析以评估慢性疼痛和CRP之间的相关性.
- 限制立方线 (RCS) 分析以评估非线性关系和剂量反应效应.
主要成果:
- 在加权样本 (250,814,660.8) 中,有27.1%的人报告慢性疼痛.
- 患有慢性疼痛的个体表现出显著更高的CRP水平 (P < 0.001).
- 与最低四分位数 (≤0.09 mg/dL) 相比,最高CRP四分位数 (>0.52 mg/dL) 与32%的慢性疼痛风险增加有关.
结论:
- 在美国成年人中,CRP水平升高与慢性疼痛之间存在显著的相关性.
- 较高的CRP水平与经历慢性疼痛的可能性更高有关.
- 需要进一步的研究来确定因果关系并阐明潜在的机制.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
43
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
43
01:25Analgesia and Pain Management
429
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
429
01:44Nociception
27.7K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.7K
01:27Psychoneuroimmunology: Cardiovascular Disease
25
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
25