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在治疗脑髓母细胞瘤期间进行周周血管空间成像

Ruitian Song¹, John O Glass¹, Shengjie Wu²

¹Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

|February 7, 2025

概括

放射治疗在儿科脑髓母细胞瘤患者中增加了周血管空间 (PVS),而化疗和时间减少了它们. 麻醉和分流也会影响PVS的体积.

科学领域:

神经成像是一种神经成像.
儿科瘤学儿科瘤学
放射治疗研究放射治疗研究

背景情况:

周血管空间 (PVS) 是大脑血管周围充满液体的隔间.
放射治疗和化疗对儿科骨髓母细胞瘤 (MB) 的PVS的影响尚不清楚.

研究的目的:

调查放射治疗和化疗对儿科MB患者PVS的影响.
在四个时间点分析PVS体积和比率的变化:基线,放射治疗后,化疗后和随访后.

主要方法:

利用了来自241名MB患者的778张MRI扫描.
在T1加权的MPRAGE图像 (3T西门子MRI) 上使用弗兰吉波器对白质的细分PVS.
使用完整和配对统计模型分析了PVS体积和比率.

主要成果:

放射治疗后PVS体积和比率增加,但在化疗期间下降.
从化疗完成到随访,PVS水平再次上升.
麻醉和分流程序与PVS体积发生显著变化有关.

结论:

脊辐射可以提高儿科MB患者的PVS.
化疗和照射后的时间导致PVS的减少.
麻醉和分流装置的放置是影响PVS测量的因素.

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