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Updated: May 29, 2025

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
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通过使用药理平衡建模的GluN2A选择性对抗剂对全性N-甲基-d-酸盐受体调节的评估

James S Lotti1, Jaron Jones1, Jill C Farnsworth1

  • 1Center for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, Montana.

Molecular pharmacology
|February 7, 2025
PubMed
概括

一个新的模型量化了N-甲基-d-酸盐 (NMDA) 受体全调节剂,揭示了结合亲和力和疗效的差异. 这有助于开发针对大脑疾病的向疗法,通过了解连接体-受体相互作用.

关键词:
艾洛斯特里克调制 (Allosteric) 是一种调制.药物受体理论 药物受体理论电力生理学 电力生理学离子型谷氨酸受体 离子型谷氨酸受体结合体带离子通道的离子通道非竞争性的对抗主义.

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