在辅助生殖技术后,子宫内膜癌的长期风险
Mandy Spaan1,2,3, Alexandra W van den Belt-Dusebout1,4, Cornelis B Lambalk5
1Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Human reproduction (Oxford, England)
|February 7, 2025
概括
在接受辅助生殖技术 (ART) 治疗的妇女中,子宫内膜癌的风险不会增加. 这一发现与一般人群和不接受ART的不孕期妇女相比是一致的.
科学领域:
- 生殖医学 生殖医学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 人们对辅助生殖技术 (ART) 与子宫内膜癌风险之间的潜在联系存在担忧.
- 现有的研究对卵巢刺激和特定的不孕症诊断对子宫内膜癌的影响提出了相互矛盾的发现.
- 本研究通过调查ART治疗妇女的长期子宫内膜癌风险来解决这些问题.
研究的目的:
- 评估女性在辅助生殖技术 (ART) 治疗后长期随访后患子宫内膜癌的风险.
- 将ART治疗妇女的子宫内膜癌风险与普通人口进行比较.
- 为了比较ART治疗妇女的子宫内膜癌症风险与没有接受ART的不孕妇女.
主要方法:
- 一项全国性的历史性队列研究 (OMEGA-队列) 涉及30625名接受ART的妇女和9988名不接受ART的不孕妇女.
- 随访时间中位数为24年,子宫内膜癌发病率通过荷兰癌症登记处确定.
- 风险评估使用人年分析与一般人群相比,以及多变量考克斯回归分析,比较ART和非ART组.
主要成果:
- 与一般人群 (SIR=1.19) 或非ART组 (aHR=1.11) 相比,在ART组中没有观察到子宫内膜癌风险的显著增加.
- 子宫内膜癌的风险与随访时间或ART周期的数量没有相关性.
- 肥胖妇女和子宫内膜异位症患者的风险较高,但不管 ART 治疗如何,孕期妇女和口服避孕药使用者风险较低.
结论:
- 这项研究提供了令人放心的证据,即ART治疗与子宫内膜癌的风险增加无关.
- 由于随访时的中位年龄相对较小,建议进行进一步的长期随访 (10-15年).
- 需要进行额外的大规模研究,以进一步调查接受过ART的女性的子宫内膜癌风险.
关键词:
在体外受精体外受精.艺术 艺术 艺术 艺术在这个过程中,IVF IVF.辅助生殖技术是一种辅助生殖技术.这是子宫内膜癌的癌症.流行病学流行病学药物生育药物生育药物生育药物的平价性.亚生育能力 亚生育能力更多相关视频
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