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Updated: May 29, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

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MTA-合作PRMT5抑制剂:通过基于结构的设计来切换机制

Kevin M Cottrell1, Douglas A Whittington1, Kimberly J Briggs1

  • 1Tango Therapeutics, 201 Brookline Ave, Boston, Massachusetts 02215, United States.

Journal of medicinal chemistry
|February 7, 2025
PubMed
概括

研究人员发现了新的化合物,可以通过MTAP删除选择性地杀死癌细胞. 这些化合物通过结合甲基氨酸 (MTA) 而不是S-adenosyl-l-methionine (SAM) 来向PRMT5蛋白,提供了一种新的治疗策略.

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