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Updated: May 29, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

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无化-PTEN的非自然链接的deubiquitinase处理

Reina Iwase1, Isabella Jaen Maisonet2, Kwangwoon Lee1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, United States; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States.

Bioorganic chemistry
|February 7, 2025
PubMed
概括

研究人员探索了如何使用一种新型的氨基Ala-Cys链接将二维基基提纳酶 (去除无素的酶) 处理单双基提纳PTEN. 几个USP家族deubiquitinases有效地处理了这种联系,帮助了deubiquitinase活性研究.

关键词:
杜比奎廷酶的使用方法在这里,我们可以看到PTEN.蛋白质半合成 蛋白质半合成乌比奎丁是一种存在的药物.

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