阐明第一个中国草药配方Shuangxia Decoction的机制,使用多omics技术缓解失眠
Runhua Liu1, Hao Wu2, Jianmin Zhang3
1Department of Pharmacy, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
概括
舒安西亚开 (SXD) 通过减少氧化应激和改善肠道健康,有效治疗失眠. 催眠素被确定为睡眠剥夺的可靠生物标志物,提供新的诊断潜力.
科学领域:
- 综合医学是一个整体的医学.
- 药理学 药理学是指药理学的学科.
- 代谢学 代谢学 代谢学
- 微生物组学 微生物组学
背景情况:
- 舒旺西亚 (Shuangxia Decoction,简称SXD) 是一种源自Pinellia ternata和Prunella vulgaris的传统中国草药配方,专门用于治疗失眠.
- SXD在治疗失眠方面有着悠久的临床使用历史,这突出了其在睡眠障碍方面的治疗潜力.
研究的目的:
- 用先进的多omics技术来阐明Shuangxia Decoction (SXD) 对抗失眠的潜在机制.
- 调查SXD中的活性化合物,如罗斯马林酸 (RA),对其抗失眠作用的特定贡献.
主要方法:
- 网络药理学被用来识别关键活性化合物和SXD对失眠的分子标.
- 在睡眠剥夺 (SD) 的小鼠模型中评估了药动力学效应.
- 血清和下丘脑代谢学,肠道微生物群分析 (16S rRNA测序) 和西部分离被用于揭示SXD的生物机制,重点是罗斯马林酸 (RA).
主要成果:
- 网络药理学确定了三种活性化合物和SXD治疗失眠的四个核心点.
- 睡眠不足小鼠的代谢分析显示,血清和下丘脑代谢物,包括素,含有 purin代谢和 arginine/proline代谢途径的显著变化.
- 罗斯马林酸 (RA) 在减少氧化应激,恢复肠道微生物平衡,改善肠道屏障功能 (升级ZO-1,奥克卢丁,克劳丁) 和激活Nrf2信号通路方面表现出有效性.
结论:
- 舒安西亚开 (SXD) 在缓解睡眠剥夺 (SD) 症状方面表现出显著的有效性.
- 罗斯马林酸 (RA) 是SXD的关键成分,通过调节紧结蛋白和Nrf2通路来改善SD诱导的氧化应激和肠道失调.
- 催眠素被提议作为诊断临床睡眠剥夺的潜在和可靠的生物标志物.
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