Dendrobium officinale 提取物对大鼠中阿司匹林诱导的胃病变的保护作用
Xinran Wang1, Huazhong Xiong2, Juhui Qiao1
1Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 1035 Boshuo Road, Changchun, Jilin 130117, China.
Molecular immunology
|February 7, 2025
概括
原始的Dendrobium officinale (DE) 提取物通过减少炎症和氧化应激来防止阿司匹林诱导的胃病变 (ASA). DE增强抗氧化活性和粘膜防御因素,支持其作为胃营养素的作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 传统中国医药 传统中国医药
背景情况:
- 阿司匹林 (ASA) 是一种常见的非类固醇抗炎药物,已知会导致胃粘膜损伤.
- 丹德罗 (Dendrobium officinale,简称DE) 是一种具有潜在治疗功能的中国传统医药.
研究的目的:
- 研究Dendrobium officinale提取物 (DE) 对抗阿司匹林诱导的胃病变的保护作用和潜在机制.
- 探索DE作为传统中医药产品中用于胃保护的成分的潜力.
主要方法:
- 建立了一种阿司匹林诱导的胃病变的老鼠模型.
- 鼠被用DE治疗了五天,以评估其治疗效果.
- 分析了胃组织中的关键炎症调解剂,抗氧化成分和防御因素.
主要成果:
- 治疗DE显著改善了阿司匹林诱导的胃粘膜脱落和出血病变.
- DE抑制了炎症媒介体 (IL-6,IL-1β,TNF-α,MPO,COX-2) 的分泌.
- DE上调了抗氧化活性 (T-SOD,GSH-Px) 和防御因子 (TFF,EGF,EGFR),涉及NF-κB/Nrf-2/HO-1信号通路.
结论:
- 丹德罗 (Dendrobium officinale) 提取物 (DE) 对抗阿司匹林诱导的病变具有显著的胃保护作用.
- DE通过减轻氧化应激,增强粘膜防御和调节炎症反应来起作用.
- 作为一种潜在的胃粘膜营养物质,DE显示出有前途,可以预防胃病变.
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