全球热气候指数对尿酸水平和尿酸过高的影响:来自大规模人口研究的见解
Yufen Zheng1, Minya Jin1, Linyan Cheng1
1Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Zhejiang 317000, China; Key Laboratory of System Medicine and Precision Diagnosis and Treatment of Taizhou, Zhejiang 317000, China.
International immunopharmacology
|February 7, 2025
概括
更高的普世热气候指数 (UTCI) 水平与尿酸 (UA) 水平的增加以及高尿素血的风险增加有关,特别是在男性中. 这表明UTCI可以帮助预测UA波动,并为个性化痛风管理策略提供信息.
科学领域:
- 环境健康 环境健康
- 生物气象学生物气象学
- 临床生物化学 临床生物化学
背景情况:
- 高尿路血是病,心血管疾病和痛风的重要危险因素.
- 气象条件显然会影响体内的尿酸 (UA) 水平.
研究的目的:
- 调查通用热气候指数 (UTCI) 和尿酸 (UA) 水平之间的关联.
- 确定UTCI,UA水平与发展高尿路血的风险之间的关系.
主要方法:
- 对209,826名参与者 (2019-2023) 的健康检查数据进行了回顾性分析.
- 检查了UTCI,UA水平和高尿路血的患病率之间的相关性.
- 统计分析以评估UTCI对UA水平和超尿路血症风险的影响,跨人口和季节.
主要成果:
- 超尿路血的患病率为18.4%,男性 (31.5%) 显著高于女性 (3.4%).
- 根据性别,年龄和季节,UA水平有很大差异,夏季的水平最高,冬季的水平最低.
- 增加的UTCI类与高的UA水平和高尿素血风险正相关,在UTCI类9观察到显著增加.
结论:
- UTCI类与UA水平和高尿血症风险密切相关.
- UTCI作为一个有价值的生物气象指标,用于预测UA波动.
- 研究结果支持基于气候条件的个性化策略,以预防和管理高尿血症.
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