侧边缘在口腔癌中的瘤学意义
Muthuswamy Dhiwakar1, Sneha Kamalakkannan1, Deeksha Dhiwakar2
1Department of Otolaryngology-Head and Neck Surgery, Kovai Medical Center and Hospital, Coimbatore 641014, India.
Oral oncology
|February 7, 2025
概括
侧边缘 (LM) 在口腔癌手术中最常接近1毫米. 一个接近的LM独立地预测了较差的局部无复发生存率 (LRFS) 和无疾病生存率 (DFS).
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 头部和部癌症研究研究
背景情况:
- 口腔癌手术需要仔细的边际评估,以获得最佳的结果.
- 侧边缘 (LM),最接近皮肤的平面,尚未专门评估其在口腔癌切除中的瘤学意义.
研究的目的:
- 为了确定侧边缘 (LM) 的瘤学意义,在接受口腔癌初级手术的患者中.
- 与其他边缘相比,评估密切LM (≤1毫米) 的频率及其与复发和生存的关联.
主要方法:
- 一项队列研究包括216名先前未接受治疗的口腔癌患者,他们正在接受初级手术.
- 根据临床参与或靠近口腔部的距离,切除了脸皮肤.
- 分析的结果包括LM≤1mm的频率,其与局部无复发生存率 (LRFS) 和无疾病生存率 (DFS) 的关联,以及皮肤切除的影响.
主要成果:
- 在67名患者中,至少有一个边缘≤1毫米,LM占54% (36名患者).
- 一个LM≤1毫米是不成比例的常见 (p<0.001) 和独立与更糟糕的LRFS和DFS相关.
- 与切除相比,皮肤的保存与LM≤1mm的更高率和LM尺寸更小 (p <0.05) 相关.
结论:
- 侧边缘是口腔癌手术中近切除边缘 (≤1毫米) 最常见的部位.
- 侧边边际≤1毫米是较差LRFS和DFS的显著预测因素,独立于其他边际状态.
- 外科医生应该考虑较低的边缘组织切除门,包括皮肤,因为皮肤的保存与较高的侧边缘密切的发病率有关.
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