铁对生长,抗氧化能力,肠道形态和肠道屏障的剂量影响在黄色羽毛肉中
1Key Laboratory of Animal Science of State Ethnic Affairs Commission, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, PR China; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, PR China.
Poultry science
|February 7, 2025
概括
肉饮食中过度补充铁对生长,肠道健康和抗氧化功能产生负面影响. 黄羽肉被养高铁含量 (≥160毫克/公斤) 经历了增长减少,肠道损伤和氧化应激,表明在标准饮食中不需要额外的铁.
科学领域:
- 动物营养 动物营养
- 禽畜科学 禽畜科学 禽畜科学
- 胃肠道生理学 胃肠道生理学
背景情况:
- 铁是肉生长和健康的重要营养素.
- 最佳的铁含量对于维持肠道完整性和抗氧化能力至关重要.
- 了解铁的剂量依赖作用对于制定有效的肉饮食至关重要.
研究的目的:
- 调查不同铁 (Fe) 补充水平对黄色羽毛肉的影响.
- 评估食铁对生长性能,抗氧化状态,小肠组织学和肠道屏障功能的影响.
- 为了确定黄色羽毛肉的最佳食铁度.
主要方法:
- 720只一天大的雄性黄羽肉被分配给9种饮食治疗,铁含量从0到1280毫克/公斤不等.
- 评估了生长表现,血和组织度的恶意甲基 (MDA),小的高度,密室深度,分泌性免疫球蛋白A (sIgA),二胺氧化酶 (DAO) 活性,以及头基因表达 (ZO-1,ocludin,claudin-1).
- 进行了统计分析,以确定对补充铁的线性和二次反应.
主要成果:
- 增加的食铁线性地减少了平均每日取 (ADG) 和平均每日料摄入量 (ADFI).
- 较高的铁含量导致MDA度增加,小的高度降低,并降低了SIGA水平.
- 铁补充剂超过160毫克/千克损害了肠道屏障功能,由紧密结蛋白 (ZO-1,ocludin,claudin-1) 的表达减少表明.
- 杰纳的DAO活性显示出二次反应,在160mg/kg铁下观察到的最高活性.
结论:
- 标准的玉米-大豆为基础的饮食黄羽肉不需要额外的铁补充.
- 长期暴露于高铁含量 (≥160 mg/kg) 会诱导氧化应激并损害肠道屏障功能.
- 过度补充铁可以抑制生长,并对黄色羽毛 brojlers 的整体健康产生负面影响.
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